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HBN-1 (IV)

Post-cardiac Resuscitation [Primary Indication]

Traumatic Brain Injury

Acute Ischemic Stroke

Spinal Cord Injury

Sepsis: severe sepsis and septic shock

Organ Transplant

Myasthenia Gravis (Acute Phase)

Phase I study in patients planned

NIH CMC/TOX completed for all indications

Existing and new translational models being



HBN-100 (Oral / IV)

Note: Different components from HBN-1

Mild concussion

Menopausal hot flashes

Multiple Sclerosis; Duchenne Muscular Dystrophy; Schwartz-Jampel Syndrome

Myasthenia Gravis (chronic / situational)

Progeria [Primary Indication]

Life Extension (General Population)
Acute Indications (IV formulation)

To be evaluated in NFL concussion model


Planning underway

Planning underway

Progeria mouse model study collaboration

Rapid regulatory pathway
Linked to Progeria development