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Indication

Status

HBN-1 (IV)

Post-cardiac Resuscitation [Primary Indication]


Traumatic Brain Injury


Acute Ischemic Stroke


Spinal Cord Injury


Sepsis: severe sepsis and septic shock


Organ Transplant


Myasthenia Gravis (Acute Phase)

Phase I study in patients planned


NIH CMC/TOX completed for all indications

Existing and new translational models being

developed

 

HBN-100 (Oral / IV)

Note: Different components from HBN-1

Mild concussion


Menopausal hot flashes


Multiple Sclerosis; Duchenne Muscular Dystrophy; Schwartz-Jampel Syndrome


Myasthenia Gravis (chronic / situational)


Progeria [Primary Indication]


Life Extension (General Population)
Acute Indications (IV formulation)

To be evaluated in NFL concussion model


Preclinical


Planning underway


Planning underway


Progeria mouse model study collaboration


Rapid regulatory pathway
Linked to Progeria development